Simulate Dose Response Studies

Many Approaches

Method 1: simstudy

library(simstudy)

Warning: package 'simstudy' was built under R version 4.4.3

set.seed(1965)

def <- defData(varname="x", formula = 10, variance = 2, dist = "normal")
def <- defData(def, varname="y", formula = "3 + 0.5 * x", variance = 1, dist = "normal")
dd <- genData(250, def)

dd <- trtAssign(dd, nTrt = 4, grpName = "grp", balanced = TRUE)

dd

Key: <id>
        id         x        y   grp
     <int>     <num>    <num> <int>
  1:     1 11.191960 8.949389     4
  2:     2 10.418375 7.372060     4
  3:     3  8.512109 6.925844     3
  4:     4 11.361632 9.850340     4
  5:     5  9.928811 6.515463     4
 ---                               
246:   246  8.220609 7.898416     2
247:   247  8.531483 8.681783     2
248:   248 10.507370 8.552350     3
249:   249  8.621339 6.652300     1
250:   250  9.508164 7.083845     3

Method 2: drcHelper

Method 3: drc

Method 4: DoseFinding